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Authors: Kelvin Ng, Mohammad Hossein Asadi Lari , Sze Wah Samuel Chan, Rahul Krishan Arora, Farah Qaiser, Vassi Sharlandjieva, and Sacha Noukhovich. Science Editor.
This is an exploratory study of student-run journals in STEM. Co-author Kelvin Ng shared the study's findings as a poster at the 2017 AAAS conference.
Authors: Farah Qaiser, Ryan K. C. Yuen and Danielle M. Andrade. Current Neurology and Neuroscience Reports. 2020.
Seizures can arise in neocortical, thalamocortical, limbic or brainstem networks. Here, we review recent genetic mechanisms implicated in focal and genetic generalized epilepsies.
Master Of Science Thesis | University of Toronto
In my Master's thesis, I describe the use of whole-genome sequencing (WGS) to conduct a genome-wide investigation of rare genetic variation in two cohorts.
Farah Qaiser, Yue Yin, Carolyn B. Mervis, Colleen A. Morris, Bonita P. Klein-Tasman, Elaine Tam, Lucy R. Osborne and Ryan K. C. Yuen. Orphanet Journal of Rare Diseases. 2021.
Duplication of the 7q11.23 chromosome region (Dup7) is one of the most frequent recurrent types of genetic variation found in individuals with autism spectrum disorder (ASD). But based on gold-standard assessments, only 19% of Dup7 carriers have ASD, suggesting that additional genetic factors are necessary to manifest ASD. In this study, we carried out whole-genome sequencing analysis of 20 Dup7 carriers: nine with ASD (Dup7-ASD) and 11 without ASD (Dup7-non-ASD) to assess the contribution of additional genetic variants to the Dup7 phenotype.
Farah Qaiser, Tara Sadoway, Yue Yin, Quratulain Zulfiqar Ali, Charlotte M Nguyen, Natalie Shum, Ian Backstrom, Paula T Marques, Sepideh Tabarestani, Renato P Munhoz, Timo Krings, Christopher E Pearson, Ryan K C Yuen, and Danielle M Andrade. Brain Communications, 2021.
Epilepsies are a group of common neurological disorders with a substantial genetic basis. Despite this, the molecular diagnosis of epilepsies remains challenging due to how varied epilepsies are.
We used whole-genome sequencing to evaluate a cohort of adults with unexplained developmental and epileptic encephalopathies (n = 30), for whom prior genetic tests were negative or inconclusive.