Academic Publications

Academic Publications
Have a question about any of these five manuscripts? Get in touch!
Student-Run Academic Journals in STEM: A Growing Trend in Scholarly Communication
Authors: Kelvin Ng, Mohammad Hossein Asadi Lari , Sze Wah Samuel Chan, Rahul Krishan Arora, Farah Qaiser, Vassi Sharlandjieva, and Sacha Noukhovich. Science Editor.

This is an exploratory study of student-run journals in STEM. Co-author Kelvin Ng shared the study's findings as a poster at the 2017 AAAS conference.
Genetics of Epileptic Networks: from Focal to Generalized Genetic Epilepsies
Authors: Farah Qaiser, Ryan K. C. Yuen and Danielle M. Andrade. Current Neurology and Neuroscience Reports. 2020.

Seizures can arise in neocortical, thalamocortical, limbic or brainstem networks. Here, we review recent genetic mechanisms implicated in focal and genetic generalized epilepsies.
Genome-wide Investigation of Rare Genetic Variation in Epilepsy and Autism Spectrum Disorder
Master Of Science Thesis | University of Toronto

In my Master's thesis, I describe the use of whole-genome sequencing (WGS) to conduct a genome-wide investigation of rare genetic variation in two cohorts.
Rare and low frequency genomic variants impacting neuronal functions modify the Dup7q11.23 phenotype
Farah Qaiser, Yue Yin, Carolyn B. Mervis, Colleen A. Morris, Bonita P. Klein-Tasman, Elaine Tam, Lucy R. Osborne and Ryan K. C. Yuen. Orphanet Journal of Rare Diseases. 2021.
Duplication of the 7q11.23 chromosome region (Dup7) is one of the most frequent recurrent types of genetic variation found in individuals with autism spectrum disorder (ASD). But based on gold-standard assessments, only 19% of Dup7 carriers have ASD, suggesting that additional genetic factors are necessary to manifest ASD. In this study, we carried out whole-genome sequencing analysis of 20 Dup7 carriers: nine with ASD (Dup7-ASD) and 11 without ASD (Dup7-non-ASD) to assess the contribution of additional genetic variants to the Dup7 phenotype.
Genome sequencing identifies rare tandem repeat expansions and copy number variants in Lennox-Gastaut Syndrome
Farah Qaiser, Tara Sadoway, Yue Yin, Quratulain Zulfiqar Ali, Charlotte M Nguyen, Natalie Shum, Ian Backstrom, Paula T Marques, Sepideh Tabarestani, Renato P Munhoz, Timo Krings, Christopher E Pearson, Ryan K C Yuen, and Danielle M Andrade. Brain Communications, 2021.
Epilepsies are a group of common neurological disorders with a substantial genetic basis. Despite this, the molecular diagnosis of epilepsies remains challenging due to how varied epilepsies are.

We used whole-genome sequencing to evaluate a cohort of adults with unexplained developmental and epileptic encephalopathies (n = 30), for whom prior genetic tests were negative or inconclusive.

This study was featured in a news piece by the University Health Network. This study was also discussed in a Scientific Commentary in the Brain Communications journal.

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Have a question about any of these five manuscripts? Get in touch!

Student-Run Academic Journals in STEM: A Growing Trend in Scholarly Communication

Genetics of Epileptic Networks: from Focal to Generalized Genetic Epilepsies

Genome-wide Investigation of Rare Genetic Variation in Epilepsy and Autism Spectrum Disorder

Rare and low frequency genomic variants impacting neuronal functions modify the Dup7q11.23 phenotype

Farah Qaiser, Yue Yin, Carolyn B. Mervis, Colleen A. Morris, Bonita P. Klein-Tasman, Elaine Tam, Lucy R. Osborne and Ryan K. C. Yuen. Orphanet Journal of Rare Diseases. 2021.

Genome sequencing identifies rare tandem repeat expansions and copy number variants in Lennox-Gastaut Syndrome

Farah Qaiser, Tara Sadoway, Yue Yin, Quratulain Zulfiqar Ali, Charlotte M Nguyen, Natalie Shum, Ian Backstrom, Paula T Marques, Sepideh Tabarestani, Renato P Munhoz, Timo Krings, Christopher E Pearson, Ryan K C Yuen, and Danielle M Andrade. Brain Communications, 2021.